Harry Lennix has had supporting roles in films such as the The Matrix series, The Five Heartbeats, the Spike Lee film Get on the Bus, Ray, and Barbershop 2: Back in Business. In television he had a recurring role in Diagnosis: Murder as Agent Ron Wagner, as well as a voice-over role in the Legion of Super Heroes animated series. He also starred in the ABC TV series Commander in Chief and the movie Titus as Aaron the Moor. He had a recurring role in the sixth season of 24 as fictional Muslim civil rights activist Walid Al-Rezani. He appeared on the show House MD as a paralyzed jazz trumpet player. He also appeared in 6 episodes of ER (TV Series) as Dr. Greg Fischer. The past few years he starred in the Broadway show Radio Golf, directed "Fly Like Mercury" filmed Resurrecting the Champ, Across the Universe and just finished filming State of Play.
He has been cast as Boyd Langton in Joss Whedon's series Dollhouse which is currently running on Fox.